The businesswoman said she was too busy to commit time to the filming schedule, but added she had “thoroughly enjoyed” her time on the show.
Speaking about her decision Hoppen said: “It has been a privilege to be part of a programme which champions entrepreneurs. I’ve had a brilliant time and made several successful investments and I will miss my fellow judges and I’m sure someone amazing will fill my seat.”
“However, due to a packed schedule and international commitments… I sadly cannot commit to the filming schedule. I have thoroughly enjoyed my time on Dragons’ Den and met many inspiring entrepreneurs along my journey. I will continue to work and invest in young entrepreneurs.
“I wish everyone on the show the best luck. What’s left to say but ‘I’m out.'”
A replacement for Hoppen has yet to be announced.
The designer replaced previous Dragon Hilary Devey, who also appeared on the programme for just two series.
Business Maters columnist Duncan Bannatyne has also announced the current series will be his last after a 10-year run.
It leaves Peter Jones as the only investor from the original series line-up.